Solve your most complex genomes
Dovetail’s linked-read chemistry allows for flexible capture of both large genomic changes like translocations all the way down to single nucleotide variants. Our high resolution genomic data output uncovers somatic variations, 3D chromatin architecture, and achieves haplotype-resolved assemblies.
Linked-reads for
Watch the LinkPrep technology overview for 3D genomics applications.
One data type for all your chromatin research questions
A complete solution—sample to sequence to insight, we have you covered with our team of support scientists and our bioinformatics portal.
Explore our linked-read solutions across applications
Genome Assembly
3D Genomics
Genetic Variation
What is a linked-read?
Linked-read is a term for any genomic sequencing output that has additional oligo information. Other examples of types of linked-reads include droplet single cell sequencing and tell-seq for looking at single molecule information.
Dovetail Genomic’s linked-read assays connect positional DNA-DNA relationships to sequencing data through proximity ligation oligo sequences to provide spatial information about the DNA in the nucleus.
Why Dovetail linked-read?
Linked-read sequencing overcomes the linear limitations of other short-read approaches to enable capture of long-range chromatin information including structural variations with short range oligo sequences. The flexibility of short range sequences with long range information enables high resolution genomes revealing haplotype resolution, somatic variants (SNV, InDel, CNV) and unbiased 3D genomics—without sacrificing sequencing depth or data quality.
Why Dovetail Genomics?
A legacy of solving complex genomes
Dovetail Genomics started in 2013 with HiRise, a revolutionary Hi-C assay that achieved the highest-resolution genome assemblies of any assay. With Micro-C and Omni-C, Dovetail made great advancements in genome libraries, through unbiased chromosome digestion and proximity ligation. Since then Dovetail has remained committed to innovation and uncovering all the mysteries of the genome, expanding into more applications even faster than before, with its single-day assay; LinkPrep technology.